lsd1 inhibitor screening kit (Cayman Chemical)
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lsd1 inhibitor screening kit
Lsd1 Inhibitor Screening Kit, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lsd1+inhibitor+screening+assay+kit/lsd1+inhibitor+screening+assay+kit/pm38968905-350-17-26
Average 90 stars, based on 1 article reviews
Lsd1 Inhibitor Screening Kit, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
https://www.bioz.com/product/lsd1+inhibitor+screening+assay+kit/lsd1+inhibitor+screening+assay+kit/pm38968905-350-17-26
Average 90 stars, based on 1 article reviews
lsd1 inhibitor screening kit - by Bioz Stars,
2026-09
90/100 stars
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Screening Assay:Article Title: Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells Article Snippet: .. Article Title: LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function Article Snippet: .. The LSD1 inhibition assay was performed using the Article Title: The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection. Article Snippet: .. LSD1 enzymatic activity was measured in whole cell extracts with an Article Title: Design, synthesis, and biological evaluation of coumarin analogs as novel LSD1 inhibitors. Article Snippet: Correspondence Dongmei Zhao, Key Laboratory of Structure‐ Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, 110016 Shenyang, China.. Email: dongmeiz-67@163.com Abstract The abnormal expression of lysine‐specific histone demethylase 1 (LSD1) is associated with different cancer types, and it is increasingly recognized as a potential therapeutic target in oncology.. Here, utilizing core hopping and conformational restriction strategies, we designed and synthesized a series of coumarin analogs that were shown to be potent LSD1 inhibitors in the enzyme assay. Article Title: Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Article Snippet: A series of novel cyanopyrimidine-hydrazone hybrids were synthesized and characterized with various spectroscopic techniques.. The synthesized compounds were tested at NCI, USA, on a 60-cell line panel and most of the compounds showed remarkable cytotoxic activity against different cancer cell lines.. Compound 5a was found to be the most potent compound of the series and it was further selected for five dose assays wherein it exhibited GI50 value of 0.414 μM and 0.417 μM against HOP-62 and OVCAR-4 cell lines respectively. Article Title: The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection Article Snippet: .. LSD1 enzymatic activity was measured in whole cell extracts with an Enzyme Inhibition Assay:Article Title: Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells Article Snippet: .. Article Title: Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Article Snippet: A series of novel cyanopyrimidine-hydrazone hybrids were synthesized and characterized with various spectroscopic techniques.. The synthesized compounds were tested at NCI, USA, on a 60-cell line panel and most of the compounds showed remarkable cytotoxic activity against different cancer cell lines.. Compound 5a was found to be the most potent compound of the series and it was further selected for five dose assays wherein it exhibited GI50 value of 0.414 μM and 0.417 μM against HOP-62 and OVCAR-4 cell lines respectively. Activity Assay:Article Title: Discovery of novel sulphonamide hybrids that inhibit LSD1 against bladder cancer cells Article Snippet: .. Article Title: The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection. Article Snippet: .. LSD1 enzymatic activity was measured in whole cell extracts with an Article Title: Design, synthesis, and biological evaluation of coumarin analogs as novel LSD1 inhibitors. Article Snippet: Correspondence Dongmei Zhao, Key Laboratory of Structure‐ Based Drug Design & Discovery of Ministry of Education, Shenyang Pharmaceutical University, 110016 Shenyang, China.. Email: dongmeiz-67@163.com Abstract The abnormal expression of lysine‐specific histone demethylase 1 (LSD1) is associated with different cancer types, and it is increasingly recognized as a potential therapeutic target in oncology.. Here, utilizing core hopping and conformational restriction strategies, we designed and synthesized a series of coumarin analogs that were shown to be potent LSD1 inhibitors in the enzyme assay. Article Title: Synthesis, biological evaluation and docking studies of methylene bearing cyanopyrimidine derivatives possessing a hydrazone moiety as potent Lysine specific demethylase-1 (LSD1) inhibitors: A promising anticancer agents. Article Snippet: A series of novel cyanopyrimidine-hydrazone hybrids were synthesized and characterized with various spectroscopic techniques.. The synthesized compounds were tested at NCI, USA, on a 60-cell line panel and most of the compounds showed remarkable cytotoxic activity against different cancer cell lines.. Compound 5a was found to be the most potent compound of the series and it was further selected for five dose assays wherein it exhibited GI50 value of 0.414 μM and 0.417 μM against HOP-62 and OVCAR-4 cell lines respectively. Article Title: The Epigenetic Controller Lysine-Specific Demethylase 1 (LSD1) Regulates the Outcome of Hepatitis C Viral Infection Article Snippet: .. LSD1 enzymatic activity was measured in whole cell extracts with an Inhibition:Article Title: LSD1 promotes prostate cancer reprogramming by repressing TP53 signaling independently of its demethylase function Article Snippet: .. The LSD1 inhibition assay was performed using the Transformation Assay:Article Title: Microbial transformation of capsaicin by several human intestinal fungi and their inhibitory effects against lysine-specific demethylase 1. Article Snippet: Capsaicin widely exists in the Capsicum genus (e.g., hot peppers) and is commonly used as a food additive or medicinal material.. In this work, microbial transformation of capsaicin was performed based on the three cultivated human intestinal fungi.. Fourteen metabolites were obtained, and their chemical structures were elucidated by spectroscopic data analysis, including 13 compounds with undescribed structures. |